Review Article CODEN: IJPRNK ISSN: 2277-8713 Jaimala Sharma, IJPRBS, 2015; Volume 4(2): 130-148 IJPRBS

The quinoline ring plays an important role in many biological systems. Their chemical Synthesis is flexible, can be easily adapted to prepare new derivatives and rationally devised structures, and hopefully can be a source of useful drugs in future. Anticancer activities have been studied for many quinoline derivatives. It has been known that quinoline derivatives may act as anticancer agents through a variety of mechanisms with the most common mechanism being the inhibition of tyrosine kinase isozymes. Several synthesized compounds of quinoline and pyrimidoquinoline having a sulfonamide moiety showed interesting cytotoxic activities. Combination of quinoline nucleues with sulfonamide moieties has received a great attention in seeking for novel anticancer agents. Several quinoline sulfonamide derivatives showed potent anticancer activity as phosphoinisitol kinase (PI3K) inhibitors. Quinoline-benzene sulfonamide nuclei produce potent cytotoxicity against the hepatic cancer cells. Quinolines and pyrimido [4,5-b]quinolines bearing biologically active sulfonamide is a new class of antitumor agents. Potential anticancer agents of a series of tetracyclic indenoquinolines have in vitro antiproliferative activities against breast (MCF-7), lung epithelial (A-549), and cervical (HeLa) adenocarcinoma cells. New quinoline derivatives with high purity and promising cytotoxic effect were synthesized and considered as a good anticancer drug candidate. Some isoquinolines interact either with topoisomerase or they form DNA-intercalated molecular complexes and show promising cytotoxic effect. Recent demonstrations reveal that quinoline carboxylic acid and their analogues can be used as potential anticancer agent. Some isoquinolines interact either with topoisomerase or they form DNA-intercalated molecular complexes and show promising cytotoxic effect. Quinoline derivatives can efficiently inhibit cancer cell proliferation and can be used for treating cancer, especially for treating cancers related to the Janus kinase-signal transducers. Quinoline derivative can trigger transient, p53-independent G2-M arrest in mutant p53 cells (SW620) and succeeding mitotic transition.